Degn lab

About Degn lab

The Laboratory for Lymphocyte Biology (or Degn lab for short), focuses on the role of B and T lymphocytes in health and disease, with a particular emphasis on tolerance and autoimmunity. B and T lymphocytes are the main constituents of the adaptive immune system, a branch of the immune system with the remarkable abilities of ‘learning’ and ‘memory’. We investigate these phenomena with a combination of molecular techniques, mouse models, flow and imaging cytometry, cell sorting, and advanced imaging techniques, including confocal and two-photon microscopy. Our work has implications for the development of treatments for autoimmune diseases, cancer, and infectious diseases, as well as vaccine design.

Current openings

Postdoc position in Immunology - Call closed

Department of Biomedicine

Images

“DEGN LAB” photoactivated inside the white pulp of the spleen. The marginal zone is delineated by in vivo labeling for CD169 (two-photon micrograph).
Cross-sectional confocal micrograph of a follicle in the popliteal lymph node. B cells in green, follicular dendritic cells (FDCs) in red, nuclei in blue.
Conduits of a murine lymph node visualized by FITC painting. Two-photon micrograph.
Follicular dendritic cell network. FDCs in red, macrophages and DCs in green.
Cross-sectional confocal micrograph of follicles in the popliteal lymph node. Macrophages and dendritic cells (DCs) in green, FDCs in red, B cells in blue.
Two-photon micrograph of a Peyer’s patch from an Aicda-Confetti reporter mouse, showing clusters of XFP-labeled B cells (‘Brainbow’ colors). Structural elements containing collagen are visible in blue (second harmonics).