Degn lab

About Degn lab

The Laboratory for Lymphocyte Biology (or Degn lab for short), focuses on the role of B and T lymphocytes in health and disease, with a particular emphasis on tolerance and autoimmunity. B and T lymphocytes are the main constituents of the adaptive immune system, a branch of the immune system with the remarkable abilities of ‘learning’ and ‘memory’. We investigate these phenomena with a combination of molecular techniques, mouse models, flow and imaging cytometry, cell sorting, and advanced imaging techniques, including confocal and two-photon microscopy. Our work has implications for the development of treatments for autoimmune diseases, cancer, and infectious diseases, as well as vaccine design.

Department of Biomedicine

Images

“DEGN LAB” photoactivated inside the white pulp of the spleen. The marginal zone is delineated by in vivo labeling for CD169 (two-photon micrograph).
Cross-sectional confocal micrograph of a follicle in the popliteal lymph node. B cells in green, follicular dendritic cells (FDCs) in red, nuclei in blue.
Conduits of a murine lymph node visualized by FITC painting. Two-photon micrograph.
Follicular dendritic cell network. FDCs in red, macrophages and DCs in green.
Cross-sectional confocal micrograph of follicles in the popliteal lymph node. Macrophages and dendritic cells (DCs) in green, FDCs in red, B cells in blue.
Two-photon micrograph of a Peyer’s patch from an Aicda-Confetti reporter mouse, showing clusters of XFP-labeled B cells (‘Brainbow’ colors). Structural elements containing collagen are visible in blue (second harmonics).